Industrialized Cyclist Notepad


Reporter proves Biological Passport basically useless

…except for PR purposes.

“We’d been hearing that the athletes biological passport, which is the latest tool in the fight against doping, is not quite as sensitive as people might want to think,” he says. “What we decided to do, with me being an amateur athlete, is put this passport to the test.”

He writes:It would last for 14 weeks, and have three phases. I would have my blood taken once a week and sent off to a lab for analysis. A doctor would monitor my health throughout.Baseline – weeks 1-3: establish what my “normal” blood levels are. Performance test at end of week 3Loading – weeks 4-10: undergo a program of between 2-3 micro-dose injections of EPO per week. Each injection would be supervised. Performance test at end of week 10Washout – weeks 11-14: critical phase of the experiment, when I stop taking EPO and the passport is meant to be most effective.The plan was to collect 14 blood analyses and have them put through the biological passport software to see if it would catch me.

But he wasnt testing to see if EPO works. He knows it works. He wanted to see if he could get away with doping. He took blood samples each week and sent them to have them analyzed and placed into a biological passport. “And the truth is, I was able to sail through the tests. I got away with it,” he says.

via Reporter dopes to show how easy it is to evade drug tests | Public Radio International.



Hypoxia-induced gene doping
March 20, 2014, 12:54
Filed under: Uncategorized | Tags: , , , , ,

Aha.

Numerous physical, pharmacological and/or genetic strategies exist that simulate the effects of hypoxia at the molecular and cellular level and increase expression of hypoxia-induced genes such as hypoxia-inducible factor (HIF), its downstream targets such as erythropoietin (EPO) and consequently increase red blood cell production. While hypoxia was classically achieved by exposure to high altitude (hypobaric hypoxic exposure), there are currently numerous methodologies for achieving hypoxia-induced gene doping including chambers (normobaric hypoxia), chemicals and genetic manipulation. Our basic hypothesis is that exposure to different types of hypoxia lead to both a unique ‘molecular signature’ specific to the type of hypoxia as well as core ‘molecular signature’ irrespective of the type of hypoxia. Testing the ‘molecular signatures of hypoxia’ using blood samples from athletes will detect all the different forms (of physical, small molecule and gene-based) hypoxia-induced gene doping that are currently in use (or likely to be developed in the near future) with great sensitivity and specificity.

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