Industrialized Cyclist Notepad


Hypoxia-induced gene doping
March 20, 2014, 12:54
Filed under: Uncategorized | Tags: , , , , ,

Aha.

Numerous physical, pharmacological and/or genetic strategies exist that simulate the effects of hypoxia at the molecular and cellular level and increase expression of hypoxia-induced genes such as hypoxia-inducible factor (HIF), its downstream targets such as erythropoietin (EPO) and consequently increase red blood cell production. While hypoxia was classically achieved by exposure to high altitude (hypobaric hypoxic exposure), there are currently numerous methodologies for achieving hypoxia-induced gene doping including chambers (normobaric hypoxia), chemicals and genetic manipulation. Our basic hypothesis is that exposure to different types of hypoxia lead to both a unique ‘molecular signature’ specific to the type of hypoxia as well as core ‘molecular signature’ irrespective of the type of hypoxia. Testing the ‘molecular signatures of hypoxia’ using blood samples from athletes will detect all the different forms (of physical, small molecule and gene-based) hypoxia-induced gene doping that are currently in use (or likely to be developed in the near future) with great sensitivity and specificity.

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London road casualties by user type

Chris Boardman on Helmets

British Cycling policy advisor Chris Boardman says it’s time for the cycling community to put the debate about mandatory cycle helmets to bed and get across the message that helmet use is one of the least important cycling safety measures.

Even talking about making helmets mandatory “massively puts people off” cycling, Boardman said, and likened the culture of helmet use among keen cyclists to people wearing body armour because they have got used to being shot at.

Talking to road.cc at the London Bike Show, Boardman said, “I think the helmet issue is a massive red herring. It’s not even in the top 10 of things you need to do to keep cycling safe or more widely, save the most lives.”

via Chris Boardman: "Helmets not even in top 10 of things that keep cycling safe" | road.cc.

More Boardman goodness:

http://road.cc/content/news/100104-chris-boardman-says-mps-should-be-embarrassed”-don’t-even-know-most-basic-facts”

We could use some straight talk like this in the US.



Bixi files for bankruptcy protection
January 21, 2014, 06:53
Filed under: Uncategorized | Tags: , , , , ,

Somebody tell me what to think about this.

Bixi owes the city $31.6 million on a $37-million city loan. Montreal also guaranteed a line of credit on which Bixi owes $6.4 million.That means Montreal taxpayers could be stuck with a $38-million bill, though the city hopes a sale of the international part of the business will cut that amount.Bixi also owes its suppliers $9 million.In total, then, Bixis total debt is at least $47 million.Bixi is also embroiled in multimillion-dollar lawsuits with a former software supplier.

via Bixi files for bankruptcy protection.



Three Popular Strava Segments
December 31, 2013, 19:24
Filed under: maps, Uncategorized | Tags: , , ,

stravatop3
click to enlarge



Bicycling on the rise in San Francisco
December 6, 2013, 14:40
Filed under: Uncategorized | Tags: , , , , ,

According to latest report:

http://sfmta.com/sites/default/files/SFMTA%202013%20Bicycle%20Count%20Report.pdf

sfmtacounts



more Copenhagen Wheel

13 pounds.

It doesn’t have a throttle that lets you just run it like a motorbike. It senses how you ride and gives you a boost when you need it.

Riders are given a boost as they pedal by measuring their effort, instead of using a throttle. This preserves the normal biking experience while enabling riders to bike faster, farther, and easier….All actuation of the wheel happens automatically via the pedals through sensing and control algorithms. When the rider pedals harder, such as when going uphill, the wheel pushes with increasing power. Using your smartphone with the Superpedestrian app, you can vary the level of powered assist.

via Copenhagen Wheel bike booster rolls out, available for pre-order : TreeHugger.



Cycling ‘superhighways’ backlash

London’s ‘cycling superhighways’ turned out to be nothing but paint in most cases. Some paint on the street might be nice for bikes, but don’t call it a superhighway.

Statistics show that the behavior of London\’s cyclists is rarely to blame for serious accidents. Many say the real problem is the high number of construction vehicles and hauling trucks on London\’s roads.

via London's cycling 'superhighways' prove to be super dangerous | Public Radio International.



New Paths Link Front Range Exurbs

Really fun hardpack paths.

Last month, the last major segment of the Coal Creek/Rock Creek Regional Trail was completed, bringing together a 27-mile trail network that now extends from Erie to Eldorado Springs, south of Boulder.

via 20-plus-year dream of a Boulder County prairie-to-mountain trail realized – Boulder Daily Camera.



Dale Stetina

According to multiple sources — including Boulder newspaper Daily Camera, local Colorado cycling website 303Cycling, and veteran American racer Steve Tilford — Stetina, 57, sustained life-threatening injuries when he fell from his bike while trying to avoid colliding with a car in Lefthand Canyon, a well-traveled road for riding among the Boulder cycling community.

According to the Daily Camera report, troopers who responded to the scene said that a 1999 Jeep SUV was headed westbound on Lefthand Canyon when the driver, identified as an adult male, pulled across the centerline and onto a shoulder on the opposite side of the road.

The driver then attempted to pull back into the westbound lane just as a group of cyclists headed eastbound on the roadway came around a slight bend. All of the cyclists were able to avoid the vehicle, but one rider lost control in the process of maneuvering, causing him to fall from his bike, a Colorado State Patrol spokesperson told Daily Camera.

Though Stetina was wearing a helmet, Tilford posted to his website Saturday night that he’d received an email from a friend of Stetina’s, describing his injuries as “very serious.”

“Dale did not hit the car, but hit the pavement, landing face first, suffering significant facial and ocular damage, and loss of responsiveness,” the email message read. “EMTs were on the scene rapidly, he received good care. He was flown to Boulder Community Hospital in a Flight for Life helicopter. He is there now in ICU. The CatScan diagnosis revealed brain stem injuries. The neurosurgeon describes the injuries as very serious. Dale is in tough shape. The future of Dale’s recovery is not known at this time, the doctors have offered no predictions. His vital signs are stable given the trauma he encountered. We are all hopeful.”

via Former national champion Dale Stetina in critical condition after Colorado accident – VeloNews.com.

Brain stem injury — not from hitting the road but from getting his neck twisted violently.




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